Understanding the pathophysiology of obesity is essential in order to curb the pandemic. In spite of the recent attempts to clear up the complex roots of this disorder, major gaps in knowledge still remain.

Existing data suggest that many systems regulate energy homeostasis. Research must contribute to advance the understanding of those regulatory systems through the study of the interactions between known homeostasis mechanisms, the discovery of new mechanisms, and the understanding of their role in the human-environment relationships.

Weight gain often occurs during a period of adjustment or following a hardship such as a major career challenge, loss of employment, divorce, mourning, etc. The proneness to compensate by eating comfort food is then increased.

A 1985 study conducted by Toronto researchers has shown that 75% of the cases of obesity in adults followed a significant disturbance.